Hosted by Dr Dimakatso Gumede, CSIR Senior Researcher
Macrophages are plastic cells of the haematopoietic system, and are critical for host immune response. However, chronic activation of the immune system can cause constitutive secretion of pro-inflammatory cytokines, leading to hyperinflammation. Previous studies have used human peripheral blood mononuclear cells to explore potential targets for reducing hyperinflammation, but their limitation is a lack of self-renewal. The advent of the technology in which induced pluripotent stem cells (iPSCs) are generated from skin cells, has led to the unlimited ability to derive macrophages from these cells. This iPSC technology will thus be used in this study to derive macrophages to investigate potential targets for treatment of systemic inflammation, which has been observed in SARS-CoV2 infections.