Dr Stoyan Stoychev, CSIR Senior Researcher and Head of Proteomics at ReSyn Biosciences
It has become widely recognised that profiling of the human genome alone is insufficient for diagnosing and monitoring most diseases due to the inability to gather all information related to the patient physiological state. Proteomics aim to profile the entire protein complement of an organism that is expressed under a physiological condition. Due to its dynamic nature, the proteome provides the possibility to monitor disease onset, progression, adverse drug reactions and mechanism of drug action. In this presentation we discuss the application of mass spectrometry-based proteome profiling for clinical diagnosis and precision medicine in a South African context.